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Estudis de b d domain
National Center for Biotechnology Information
Targeting bromodomain and extra-terminal proteins to inhibit neuroblastoma tumorigenesis through regulating MYCN
Bromodomain and extra-terminal domain (BET) family proteins play important roles in regulating the expression of multiple proto-oncogenes by recognizing acetylation of histones and non-histone proteins including transcription factors, which subsequently
Autor: Xiyao Shi, Ying …
S'ha publicat: 2022
Publication: Front Cel…
National Center for Biotechnology Information
Chimeric Antigen Receptors Incorporating D Domains Targeting CD123 Direct Potent Mono- and Bi-specific Antitumor Activity of T Cells
In recent years, advances in chimeric antigen receptor (CAR) T cell engineering and delivery have resulted in impressive clinical efficacy against B cell malignancies. However, continued optimization of CAR function is critical, as clinical experience
Autor: Haiying Qin, Jus…
S'ha publicat: 2019/07…
Publication: Mol Ther. …
ScienceDirect
Research Article A DNA-Binding Bromodomain-Containing Protein Interacts with and Reduces Rx1-Mediated Immune Response to Potato Virus X
Plant NLR proteins enable the immune system to recognize and respond to pathogen attack. An early consequence of immune activation is transcriptional reprogramming. Some NLRs have been shown to act in the nucleus and interact with transcription factors.
S'ha publicat: 2020/07…
Cited By: 0
Keywords: cellular im…
Frontiers
https://www.frontiersin.org/articles/10.3389/fmolb.2021.728777
Frontiers | The Functions of BET Proteins in Gene Transcription of ...
Liquid–liquid phase separation, characterized by protein and other bimolecular condensates, has emerged as a crucial membrane-less compartment implicated in biological processes including chromatin reorganization, as well as in human diseases such as neurodegenerative disorders and cancer (Krainer, … Mostra'n més
Introduction
Bromodomain and extra-terminal domain (BET) family proteins, consisting of BRD2, BRD3, BRD4, and BRDT, are important transcription … Mostra'n més
Bromodomain and Extra-Terminal Domain Proteins in Super-Enhancer Assembly
Pharmacological inhibition of the BET bromodomains has been regarded as a new therapeutic strategy targeting the transcriptional expression of c-Myc–dependent … Mostra'n més
Toxicity of Bromodomain and Extra-Terminal Domain Protein Inhibition in Vivo
BET-BD inhibitors have shown therapeutic efficacies in preclinical models. However, the role of BRD4 in the normal cell developmental process and subsequently sustained BET … Mostra'n més
Brd4 Short Isoform vs Long Isoform
The expression levels of BRD isoforms BRD4L and BRD4S seem to be determined by the function of splicing kinase SRPK1, … Mostra'n més
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Introduction
Bromodomain and Extra-Terminal Domain Proteins in Super-Enhancer Assembly
Brd4 Short Isoform vs Long Isoform
Toxicity of Bromodomain and Extra-Terminal Domain Protein Inhibition in Vivo
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Chimeric Antigen Receptors Incorporating D Domains …
ncbi.nlm.nih.gov
BET Bromodomain Proteins Function as Master ... - …
cell.com
Bromodomain biology and drug discovery - Nature
nature.com
The Bromodomain and Extra-Terminal Domain (BET) Family …
pubmed.ncbi.nlm.nih.gov
BET Bromodomain Inhibition Releases the Mediator …
pubmed.ncbi.nlm.nih.gov
Retinoblastoma protein as an intrinsic BRD4 inhibitor ... - Nature
nature.com
Recomanat en funció de les tendències • Comentaris
Nature
https://www.nature.com/articles/nrm.2016.143
Functions of bromodomain-containing proteins and their roles in ...
Lloc web5 de gen. de 2017 · Nature Reviews Molecular Cell Biology - Bromodomains (BRDs) are domains found in diverse proteins that recognize acetylated Lys residues, …
- Autor: Takao Fujisawa, Panagis Filippakopoulos, Panagis Filippakopoulos
- Publish Year: 2017
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What is a D domain?
Fry and colleagues describe the development of a class of binding domain, called D domains. They identify a series of binders to CD123 (a therapeutic target for hematologic malignancies), characterize their performance as the targeting domains in chimeric antigen receptors, and suggest an alternative to conventional scFv-based CAR designs.
Chimeric Antigen Receptors Incorporating D Domains Targeting CD123
ncbi.nlm.nih.gov
What is a bromodomain & extra-terminal domain (BET)?
Bromodomain and extra-terminal domain (BET) family proteins, consisting of BRD2, BRD3, BRD4, and BRDT, are important transcription regulators, characterized by two N-terminal acetyl-lysine (Kac) binding bromodomains (BD1 and BD2) followed by an ET domain ( Wu and Chiang, 2007; Zaware and Zhou, 2019) ( Figure 1 ).
Frontiers | The Functions of BET Proteins in Gene Transcription of
frontiersin.org
How many domains are in a BRD4 protein?
BET proteins contain several conserved domains, namely bromodomain 1 (BD1) and bromodomain 2 (BD2), an extra-terminal domain (ET), and the Ser/Glu/Asp (SEED)-rich domain region ( Fig. 1 ). Three isoforms have been reported for BRD4.
Small-molecule PROTAC degraders of the Bromodomain and ... - Scienc…
sciencedirect.com
What are BD1 and BD2 domains?
As arguably the most well-characterized domains in BET proteins, BD1 and BD2 domains, composed of the evolutionarily conserved four-helical bundle structure, function to recognize acetylated lysine in histones or transcription factors and act as readers of acetylation signals in gene transcription in chromatin ( Dhalluin et al., 1999 ).
Frontiers | The Functions of BET Proteins in Gene Transcription of
frontiersin.org
Comentaris
Nature
https://www.nature.com/articles/s41586-022-04586-4
Mapping the energetic and allosteric landscapes of protein …
Lloc web6 d’abr. de 2022 · We apply the approach to two of the most common protein interaction domains found in humans, an SH3 domain and a PDZ domain, to produce …
Nature
https://www.nature.com/articles/s41392-020-00384-4
The BET family in immunity and disease | Signal Transduction and ...
Lloc web19 de gen. de 2021 · The bromodomain and extraterminal domain (BET) family of proteins consists of four conserved mammalian members (BRD2, BRD3, BRD4, and …
- Autor: Nian Wang, Runliu Wu, Daolin Tang, Rui Kang
- Publish Year: 2021
PNAS
https://www.pnas.org/doi/10.1073/pnas.212…
Discovery of potent BET bromodomain 1 …
Lloc webConfirmed by BROMOscan, subnanomolar K d values were determined for all BET BD1 domains, and >5,000-fold selectivity was identified over BET BD2 domains by bromoKdELECT for BRD3, BRD4, and …
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523081
Targeting bromodomain and extra-terminal proteins to inhibit ...
Lloc web16 de set. de 2022 · Bromodomain and extra-terminal domain (BET) family proteins play important roles in regulating the expression of multiple proto-oncogenes by …
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612629
Chimeric Antigen Receptors Incorporating D Domains Targeting …
Lloc web7 de jul. de 2019 · Fry and colleagues describe the development of a class of binding domain, called D domains. They identify a series of binders to CD123 (a …
Frontiers
https://www.frontiersin.org/articles/10.33…
Frontiers | Bromodomain Containing Protein 4 (BRD4) …
Lloc webBromodomain-containing 4 (BRD4) is a member of the bromodomain and extra-terminal domain (BET) family of proteins that plays pleiotropic roles in epigenetic control of inflammation-inducible gene expression …
Frontiers
https://www.frontiersin.org/articles/10.33…
Frontiers | Targeting bromodomain and extra-terminal …
Lloc web16 de set. de 2022 · The N-terminal of human BET family proteins contains two conserved bromodomains (BD1 and BD2) which can recognize acetylated histones and regulate gene transcription and …
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