Plant NLR proteins enable the immune system to recognize and respond to pathogen attack. An early consequence of immune activation is transcriptional reprogramming. Some NLRs have been shown to act in the nucleus and interact with transcription factors.

In recent years, advances in chimeric antigen receptor (CAR) T cell engineering and delivery have resulted in impressive clinical efficacy against B cell malignancies. However, continued optimization of CAR function is critical, as clinical experience

We have characterized a cDNA clone, rdd (repeated D domain-like), that encodes for a secretory protein consisting of repeated domains of cysteine-rich sequence. Whole-mount in situ hybridization analysis revealed that rdd2, rdd3 and rdd4 are transiently

Protein disulfide isomerase (PDI) is the prototypic member of the PDI family of enzymes that catalyze the oxidation, reduction and isomerization of disulfide bonds. Although originally characterized as an endoplasmic reticulum protein involved in formation